HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Aminoethyl)isoquinoline-5-sulfonamide → HCID 131726994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Aminoethyl)isoquinoline-5-sulfonamide | HCID 3544 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | methyl 2-(4-chloronaphthalen-1-yl)oxyacetate | HCID 302909 | — |
| Product | HCID 131726994 | HCID 131726994 | — |
Reaction Steps
By following similar procedure as described in Example 34, DIBAL-H reduction of (4-chloro-naphthalen-1-yloxy)-acetic acid methyl ester and subsequent reductive amination with isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide gives the free amine product as a gum. The free amine is converted to the di-oxalic acid salt of the title compound as a white powder. ESIMS: m/z 456 [(M+H)+, 35Cl], 458 [(M+H)+, 37Cl].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414063B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-666d351feb5b43afba5d361b6fdceb4c |
| Source note | uspto-grants-2008_08 |