Hydrochloric Acid → HCID 69549237, compound

Participants

Reaction Steps

A 4N HCl (in 1,4-dioxane, 3 mL) solution is added to a stirred solution of [2-(2-benzyl-phenoxy)-ethyl]-{2-[(isoquinoline-5-sulfonyl)-methyl-amino]-ethyl}-carbamic acid tert-butyl ester (65.0 mg, 0.113 mmol) in anhydrous CH2Cl2 (1 mL) at ambient temperature under nitrogen. The resultant solution is stirred for 2 hours. The mixture is concentrated and the product is treated with CH3OH/EtOAc to form a white suspension. After filtration and vacuum drying, 52.5 mg (0.0957 mmol, 85% yield) of the title compound is obtained as a white solid. ESIMS: m/z 476 (M+H)+.

Provenance & Evidence