化工社化工社 化学情報印刷レポート · 研究参考用
N-(2-Aminoethyl)isoquinoline-5-sulfonamide → Isoquinoline-5-sulfonic acid {2-[2-(2-bromo-4-fluoro-phenyloxy)-ethylamino]-ethyl}-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-Aminoethyl)isoquinoline-5-sulfonamide | HCID 3544 | — |
| 反応物 | Diisobutylaluminum hydride | HCID 14487 | — |
| 反応物 | Methyl 2-(2-bromo-4-fluorophenoxy)acetate | HCID 28825613 | — |
| 生成物 | Isoquinoline-5-sulfonic acid {2-[2-(2-bromo-4-fluoro-phenyloxy)-ethylamino]-ethyl}-amide | HCID 58816145 | — |
反応手順
By following a similar procedure as described in Example 1, DIBAL-H reduction of (2-bromo-4-fluoro-phenoxy)-acetic acid methyl ester, and subsequent reductive amination with isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide gives the free amine of the title compound as a white foam. ESIMS: m/z 468 [(M+H)+, 79Br], 470 [(M+H)+, 81Br].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07414063B2 |
| 出典データセット | uspto-grants-2008_08 |
| ORD ID | ord-370a25846a6447a999db10b3efb1ecb3 |
| 出典メモ | uspto-grants-2008_08 |