HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Aminoethyl)isoquinoline-5-sulfonamide → Isoquinoline-5-sulfonic acid {2-[2-(4-chloro-2-(3-trifluoromethyl-benzyl)-phenyloxy)-ethylamino]-ethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Aminoethyl)isoquinoline-5-sulfonamide | HCID 3544 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | [4-Chloro-2-(3-trifluoromethyl-benzyl)-phenyloxy]-acetic acid methyl ester | HCID 69273829 | — |
| Product | Isoquinoline-5-sulfonic acid {2-[2-(4-chloro-2-(3-trifluoromethyl-benzyl)-phenyloxy)-ethylamino]-ethyl}-amide | HCID 58816176 | — |
Reaction Steps
By following a similar procedure as described in Example 1, DIBAL-H reduction of [4-chloro-2-(3-trifluoromethyl-benzyl)-phenyloxy]-acetic acid methyl ester, and subsequent reductive amination with isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide gives the free amine of the title compound as a clear gum. ESIMS: m/z 564 [(M+H)+, 35Cl], 566 [(M+H)+, 37Cl].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414063B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-a80dea2fdb724007a5b897d20aefa444 |
| Source note | uspto-grants-2008_08 |