HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Aminoethyl)isoquinoline-5-sulfonamide → HCID 58816144, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Aminoethyl)isoquinoline-5-sulfonamide | HCID 3544 | — |
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | HCID 44227926 | HCID 44227926 | — |
| Product | HCID 58816144 | HCID 58816144 | 71% |
Reaction Steps
By following similar procedure as described in Example 1, DIBAL-H reduction of [(4-bromo-phenyl)-tert-butoxycarbonyl-amino]-acetic acid methyl ester (aqueous Rochelle's salt work-up) and subsequent reductive amination with isoquinoline-5-sulfonic acid (2-amino-ethyl)-amide gives the free amine product as a solid (71% yield). ESIMS: m/z 549 [(M+H)+, 79Br], 551 [(M+H)+, 81Br].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414063B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-90ea6ccc7f0b4fd2922a2792c3a61533 |
| Source note | uspto-grants-2008_08 |