HCID 11097971, compound → HCID 10174511, compound

HRID 2219270Notes

Reaction equation

HRID 2219270 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@@H:10]3[O:19][C@@H:9]3[C:8]=2[CH:20]=1)([O-:3])=[O:2].[Cl:21][C:22]1[CH:23]=[C:24]([NH:28][CH2:29][C:30]2[N:31]=[N:32][N:33]([CH3:35])[N:34]=2)[CH:25]=[CH:26][CH:27]=1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@H:10]([OH:19])[C@@H:9]([N:28]([C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([Cl:21])[CH:23]=3)[CH2:29][C:30]3[N:31]=[N:32][N:33]([CH3:35])[N:34]=3)[C:8]=2[CH:20]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 11097971HCID 11097971, compoundHCID 68881260HCID 68881260, compound

Product 1

HCID 10174511HCID 10174511, compoundYield 46%

Procedure

The same procedure as step 3 of example 1 was accomplished, except for using the epoxide compound (150 mg, 0.53 mmol) obtained in step 1 of example 2 and N-(3-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine. The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:1), to give desired compound (124 mg, yield: 46%).

Workup

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=1:1)

Sources & evidence

ORD record
ord-09f8a3ac1974425ca6c3f95cb68b9792
Source dataset
uspto-grants-2008_08
Patent number
US07414068B2

Reaction notes

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