HCID 11097971, compound → HCID 10152313, compound

HRID 2219279Notes

Reaction equation

HRID 2219279 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@@H:10]3[O:19][C@@H:9]3[C:8]=2[CH:20]=1)([O-:3])=[O:2].[CH3:21][C:22]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=1[NH:29][CH2:30][C:31]1[N:32]=[N:33][N:34]([CH3:36])[N:35]=1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C@:11]([CH3:18])([CH:13]([O:16][CH3:17])[O:14][CH3:15])[C@H:10]([OH:19])[C@@H:9]([N:29]([C:23]3[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:22]=3[CH3:21])[CH2:30][C:31]3[N:32]=[N:33][N:34]([CH3:36])[N:35]=3)[C:8]=2[CH:20]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 11097971HCID 11097971, compoundHCID 68880752HCID 68880752, compound

Product 1

HCID 10152313HCID 10152313, compoundYield 47%

Procedure

The same procedure as step 3 of example 1 was accomplished, except for using the epoxide compound (300 mg, 1.07 mmol) obtained in step 1 of example 2 and N-(2,3-dimethylphenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine. The crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=2:1), to give desired compound (253 mg, yield: 47%).

Workup

  1. customThe crude product was purified by silica gel column chromatography (developing solvent-n-hexane:ethyl acetate=2:1)

Sources & evidence

ORD record
ord-3e4d0d1f449b46f28e3f784f29590dc3
Source dataset
uspto-grants-2008_08
Patent number
US07414068B2

Reaction notes

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