(2-Bromophenyl)boronic acid → HCID 23725264, compound

HRID 2219306Notes

Reaction equation

HRID 2219306 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[Br:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1B(O)O>>[Br:18][C:19]1[CH:24]=[CH:23][C:22]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 2773294(2-Bromophenyl)boronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 23725264HCID 23725264, compoundYield 41%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 2-bromophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (78 mg, 41%) which was obtained as a white solid. MS (ESI): m/e=379.9 [M+H]+.

Sources & evidence

ORD record
ord-b4c2fbd78887405b98d57efc528ab2eb
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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