(4-Propylphenyl)boronic acid → HCID 23725694, compound

HRID 2219309Notes

Reaction equation

HRID 2219309 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH2:18]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)[CH2:19][CH3:20]>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[C:4]1[N:3]=[CH:2][N:1]([C:24]2[CH:25]=[CH:26][C:21]([CH2:18][CH2:19][CH3:20])=[CH:22][CH:23]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 4100861(4-Propylphenyl)boronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 23725694HCID 23725694, compoundYield 30%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 4-propylphenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (52 mg, 30%) which was obtained as a white solid. MS (ESI): m/e=344.0 [M+H]+.

Sources & evidence

ORD record
ord-0d3d529c2e2a460b858946f765f308a7
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…