3-(Trifluoromethyl)phenylboronic acid → HCID 67420850, compound

HRID 2219310Notes

Reaction equation

HRID 2219310 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[F:18][C:19]([F:30])([F:29])[C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[C:4]1[N:3]=[CH:2][N:1]([C:24]2[CH:23]=[CH:22][CH:21]=[C:20]([C:19]([F:30])([F:29])[F:18])[CH:25]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67420850HCID 67420850, compoundYield 30%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 3-(trifluoromethyl)phenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (55 mg, 30%) which was obtained as a white solid. MS (ESI): m/e=370.0 [M+H]+.

Sources & evidence

ORD record
ord-b2a4ce8e7a5a44feaf1344825dd0f1fd
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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