3-(Methoxycarbonyl)benzeneboronic acid → HCID 67422461, compound

HRID 2219311Notes

Reaction equation

HRID 2219311 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH3:18][O:19][C:20]([C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1)=[O:21]>>[CH3:18][O:19][C:20](=[O:21])[C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)[CH:27]=1

Participants

3

Reactant 2

HCID 27347143-(Methoxycarbonyl)benzeneboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67422461HCID 67422461, compoundYield 40%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 3-methoxycarbonylphenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (65 mg, 40%) which was obtained as a white solid. MS (ESI): m/e=360.0 [M+H]+.

Sources & evidence

ORD record
ord-dbcf1107aec44b438224ef00304e240a
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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