Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 23725748, compound

HRID 2219313Notes

Reaction equation

HRID 2219313 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.F[C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[C:4]1[N:3]=[CH:2][N:1]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 178434980HCID 178434980, compound

Product 1

HCID 23725748HCID 23725748, compoundYield 24%

Procedure

As described for Example 12, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (100 mg, 0.44 mmol) using 4-fluorobenzotrifluoride instead of 4-fluoroacetophenone was converted to the title compound (40 mg, 24%) which was obtained as an off-white solid. MS: m/e=370.0 [M+H]+.

Sources & evidence

ORD record
ord-1ba6ab556c66492db97c11fd24058b8c
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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