4-Iodoanisole → HCID 67419921, compound

HRID 2219317Notes

Reaction equation

[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.I[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1>>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:20][CH:21]=1

Participants

Reactant 2

HCID 696764-Iodoanisole

HCID 178434980HCID 178434980, compound

Product 1

HCID 67419921HCID 67419921, compoundYield 15%

Procedure

As described for Example 2b, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (100 mg, 0.44 mmol) using 4-iodoanisole instead of iodobenzene was converted to the title compound (22 mg, 15%) which was obtained as a yellow gum. MS: m/e=332.3 [M+H]+.

Sources & evidence

ORD record: ord-20fab8680c61411880846177543e7eab
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

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