(2-Ethoxyphenyl)boronic acid → HCID 67421382, compound

HRID 2219319Notes

Reaction equation

HRID 2219319 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O)[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[N:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1)[CH3:19]

Participants

3

Reactant 2

HCID 2734902(2-Ethoxyphenyl)boronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67421382HCID 67421382, compoundYield 12%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 2-ethoxyphenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (21 mg, 12%) which was obtained as a white solid. MS (ESI): m/e=346.0 [M+H]+.

Sources & evidence

ORD record
ord-72d1790d7a234e71b52aeeba1de59a6d
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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