(4-Boc-Aminophenyl)Boronic Acid → HCID 67420976, compound

HRID 2219321Notes

Reaction equation

HRID 2219321 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[C:18]([NH:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1)([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[C:21]([O:20][C:18](=[O:19])[NH:25][C:26]1[CH:27]=[CH:28][C:29]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:30][CH:31]=1)([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 3613184(4-Boc-Aminophenyl)Boronic AcidHCID 178434980HCID 178434980, compound

Product 1

HCID 67420976HCID 67420976, compoundYield 5%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 4-(N-Boc-amino)phenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (10 mg, 5%) which was obtained as a white solid (ESI). MS: m/e=417.0 [M+H]+.

Sources & evidence

ORD record
ord-30d56db13b254c0dae09069bba590843
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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