(3,5-Difluorophenyl)boronic acid → HCID 23725267, compound

HRID 2219322Notes

Reaction equation

HRID 2219322 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[C:23]([F:25])[CH:24]=1>>[F:18][C:19]1[CH:20]=[C:21]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)[CH:22]=[C:23]([F:25])[CH:24]=1

Participants

3

Reactant 2

HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 23725267HCID 23725267, compoundYield 30%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 3,5-difluorophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (51 mg, 30%) which was obtained as a white solid (ESI). MS: m/e=337.9 [M+H]+.

Sources & evidence

ORD record
ord-2600d605f02b48348605d2d691edf051
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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