2-Fluoro-5-methoxyphenylboronic acid → HCID 67419988, compound

HRID 2219325Notes

Reaction equation

HRID 2219325 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=1B(O)O>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:20]=1[N:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 41572112-Fluoro-5-methoxyphenylboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67419988HCID 67419988, compoundYield 3.4%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (112.6 mg, 0.5 mmol) was converted, using 2-fluoro-5-methoxyphenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (6 mg, 3.4%) which was obtained as a white solid. MS (ESI): m/e=350.0 [M+H]+.

Sources & evidence

ORD record
ord-f955c3639dd1481d9ba8969d1a8569de
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…