4-Fluorobenzyl bromide → HCID 23725320, compound

HRID 2219332Notes

Reaction equation

HRID 2219332 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Br)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:26]=[CH:25][C:22]([CH2:23][N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 178434980HCID 178434980, compound

Product 1

HCID 23725320HCID 23725320, compoundYield 70%

Procedure

As described for Example 34, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (100 mg, 0.44 mmol) using 4-fluorobenzyl bromide instead of benzyl bromide was converted to the title compound (104 mg, 70%) as a colourless gum. MS: m/e=334.1 [M+H]+.

Sources & evidence

ORD record
ord-972984fe7a4e450781d31b36dc74562a
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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