HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyrimidine → HCID 23726021, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | HCID 178435006 | HCID 178435006 | — |
| Product | HCID 23726021 | HCID 23726021 | 47% |
Reaction Steps
As described for Example 53, 3-(3,4-difluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (78 mg, 0.3 mmol) using 2-chloropyrimidine instead of 4-fluoroacetophenone was converted to the title compound (48 mg, 47%) which was obtained as an off-white solid. MS: m/e=406.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414061B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-700c9c3cbcc349b69156e5098f94216f |
| Source note | uspto-grants-2008_08 |