Benzene, 1-fluoro-4-(trifluoromethyl)- → HCID 23725802, compound

HRID 2219353Notes

Reaction equation

HRID 2219353 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1[NH:11][CH:12]=[C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:17][O:18][C:19]=2[CH3:20])[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:28]1[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=1>>[CH2:1]([O:8][CH2:9][C:10]1[N:11]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=2)[CH:12]=[C:13]([C:15]2[C:16]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[N:17][O:18][C:19]=2[CH3:20])[N:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 67873Benzene, 1-fluoro-4-(trifluoromethyl)-HCID 178434979HCID 178434979, compound

Product 1

HCID 23725802HCID 23725802, compoundYield 13%

Procedure

As described for Example 63, 4-(2-benzyloxymethyl-1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (200 mg, 0.58 mmol) using 4-fluorobenzotrifluoride instead of 4-fluoroacetophenone was converted to the title compound (38 mg, 13%) which was obtained as a light yellow gum. MS: m/e=490.1 [M+H]+.

Sources & evidence

ORD record
ord-d966858ddb24460abe1fa564c605458c
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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