Benzamidine, hydrochloride → HCID 178434978, compound

HRID 2219357Notes

Reaction equation

HRID 2219357 reaction equation
Br[CH2:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=O.Cl.[C:18]([NH2:26])(=[NH:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:10][C:9]1[O:8][N:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]=1[C:3]1[N:25]=[C:18]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[NH:26][CH:2]=1

Participants

3

Reactant 2

HCID 80289Benzamidine, hydrochlorideHCID 27355314-(Bromoacetyl)-5-methyl-3-phenylisoxazole

Product 1

HCID 178434978HCID 178434978, compoundYield 92%

Procedure

As described for Example 57, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (1.0 g, 4 mmol) using benzamidine HCl instead of acetamidine HCl was converted to the title compound (992 mg, 92%) which was obtained as a white solid. MS: m/e=302.1 [M+H]+.

Sources & evidence

ORD record
ord-78329ad9bb80407e8bcc0389491e212e
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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