HCID 67421860, compound → HCID 67423165, compound

HRID 2219358Notes

Reaction equation

HRID 2219358 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH3:18][C:19]1[CH:24]=[CH:23][C:22](OB(C2C=CC=CC=2)O)=[CH:21][CH:20]=1>>[CH3:11][C:10]1[O:9][N:8]=[C:7]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:6]=1[C:4]1[N:3]=[CH:2][N:1]([C:22]2[CH:23]=[CH:24][C:19]([CH3:18])=[CH:20][CH:21]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 67421860HCID 67421860, compoundHCID 178434980HCID 178434980, compound

Product 1

HCID 67423165HCID 67423165, compoundYield 60.5%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (100 mg, 0.44 mmol) was converted, using 4-methylphenylphenylboronic acid (120 mg, 0.88 mmol) instead of 4-fluorophenylboronic acid, to the title compound (84 mg, 60%) which was obtained as an off-white solid. MS: m/e=316.1 [M+H]+.

Sources & evidence

ORD record
ord-8f2df18c8f4e4d40ab48da0b1fbc4f16
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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