Benzoic acid, 4-fluoro-, ethyl ester → HCID 67420630, compound

HRID 2219359Notes

Reaction equation

HRID 2219359 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH2:18]([O:20][C:21](=[O:29])[C:22]1[CH:27]=[CH:26][C:25](F)=[CH:24][CH:23]=1)[CH3:19]>>[CH2:18]([O:20][C:21](=[O:29])[C:22]1[CH:27]=[CH:26][C:25]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:24][CH:23]=1)[CH3:19]

Participants

3

Reactant 2

HCID 67976Benzoic acid, 4-fluoro-, ethyl esterHCID 178434980HCID 178434980, compound

Product 1

HCID 67420630HCID 67420630, compoundYield 72%

Procedure

As described for Example 1, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (2.25 g, 10.0 mmol) was converted, using 4-fluorobenzoic acid ethyl ester (1.54 g, 10.0 mmol) instead of 4-fluoroacetophenone, to the title compound (2.68 g, 72%) which was obtained as brown oil. MS: m/e=374.1 [M+H]+.

Sources & evidence

ORD record
ord-0dc7aadde5004affb2aba3ff4b41dff7
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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