Triethylamine → HCID 23725909, compound

Participants

Reaction Steps

To a solution of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) in DMF (2 mL), was added 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (85.9 mg, 0.45 mmol) and N-hydroxybenzotriazole (60.7 mg, 0.45 mmol), followed by adding cyclopropylmethylamine (26 mg, 0.36 mmol) and triethylamine (75 mg, 0.75 mmol). The reaction mixture was stirred at room temperature overnight. Purification by preparative HPLC on reversed phase eluting with an acetonitrile/water [0.1% aq NH3 (25%)] gradient afforded the title compound (14 mg, 13%) which was obtained as a white solid. MS m/e=398.9 [M+H]+.

Provenance & Evidence