Cyclopropanemethanamine → HCID 23725910, compound

HRID 2219362Notes

Reaction equation

HRID 2219362 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=2)[CH:17]=1.[CH:27]1([CH2:30][NH2:31])C[CH2:28]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:31][CH2:30][C:27]#[CH:28])=[O:24])=[CH:20][CH:19]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 67420918HCID 67420918, compound

Product 1

HCID 23725910HCID 23725910, compoundYield 13%

Procedure

As described for Example 71c, 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) was converted, using prop-2-ynlamine instead of cyclopropylmethylamine, to the title compound (15 mg, 13%) which was obtained as an off-white solid. MS: m/e=382.9 [M+H]+.

Sources & evidence

ORD record
ord-0f6bf731e25b4cd39e2ec38a331dc69d
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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