Cyclopentylamine → HCID 67419923, compound

HRID 2219366Notes

Reaction equation

[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][CH:19]=2)[CH:17]=1.[CH:27]1([NH2:32])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:32][C:22](=[O:24])[C:21]2[CH:20]=[CH:19][C:18]([N:16]3[CH:17]=[C:13]([C:3]4[C:4]([C:7]5[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=[CH:15]3)=[CH:26][CH:25]=2)[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 67420918HCID 67420918, compound

Product 1

HCID 67419923HCID 67419923, compoundYield 11%

Procedure

As described for Example 71c, 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) was converted, using cyclopentylamine instead of cyclopropylmethylamine, to the title compound (14 mg, 11%) which was obtained as an off-white solid. MS: m/e=413.0 [M+H]+.

Sources & evidence

ORD record: ord-a964c1b3e5c6434a94852c51e916de8a
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

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