3-Ethoxybenzeneboronic acid → HCID 67420967, compound

HRID 2219369Notes

Reaction equation

HRID 2219369 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[CH2:18]([O:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][CH:26]=1)[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:26]=[C:25]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)[CH:24]=[CH:23][CH:22]=1)[CH3:19]

Participants

3

Reactant 2

HCID 27739203-Ethoxybenzeneboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 67420967HCID 67420967, compoundYield 7%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (68 mg, 0.3 mmol) was converted, using 3-ethoxyphenylboronic acid instead of 4-fluorophenylboronic acid, to the tide compound (8 mg, 7%) which was obtained as an off-white solid. MS: m/e=346.5 [M+H]+.

Sources & evidence

ORD record
ord-2ffebf311f69473c816bad749dd0ef2e
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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