HCID 67420918, compound → HCID 67421205, compound

HRID 2219372Notes

Reaction equation

HRID 2219372 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[N:14]=[CH:15][N:16]([C:18]2[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=2)[C:21]([OH:23])=O)[CH:17]=1.CC1ON=C(C2C=CC=CC=2)C=1C1N=C[N:42]([C:44]2[CH:52]=[CH:51][C:47](C(O)=O)=CC=2)C=1>>[CH:52]1([CH2:44][NH:42][C:21](=[O:23])[C:20]2[CH:24]=[CH:25][CH:26]=[C:18]([N:16]3[CH:17]=[C:13]([C:3]4[C:4]([C:7]5[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=5)=[N:5][O:6][C:2]=4[CH3:1])[N:14]=[CH:15]3)[CH:19]=2)[CH2:47][CH2:51]1

Participants

3

Reactant 2

HCID 67420918HCID 67420918, compoundHCID 67421094HCID 67421094, compound

Product 1

HCID 67421205HCID 67421205, compoundYield 43%

Procedure

As described for Example 71c, 3-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol), instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid was converted to the title compound (50 mg, 43%) which was obtained as an off-white solid. MS: m/e=399.1 [M+H]+.

Sources & evidence

ORD record
ord-571ba2160ab2438abf6c0eb75c6bd718
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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