2-Chlorophenylboronic acid → HCID 23725321, compound

HRID 2219377Notes

Reaction equation

HRID 2219377 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1B(O)O>>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 178434980HCID 178434980, compound

Product 1

HCID 23725321HCID 23725321, compoundYield 10%

Procedure

As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-phenyl-isoxazole (68.2 mg, 0.3 mmol) was converted, using 2-chlorophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (11 mg, 10%) which was obtained as an off-white solid. MS: m/e=336.5 [M+H]+.

Sources & evidence

ORD record
ord-061d0f32b3a049f1b1f1b8304e55f6f8
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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