Cyclopentylamine → HCID 67421683, compound

HRID 2219381Notes

Reaction equation

[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][C:8]1[O:12][N:11]=[C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]=1[C:19]1[N:20]=[CH:21][N:22]([C:24]2[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=2[C:26](O)=[O:27])[CH:23]=1>>[CH:1]1([NH:6][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=2[N:22]2[CH:23]=[C:19]([C:9]3[C:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[N:11][O:12][C:8]=3[CH3:7])[N:20]=[CH:21]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 67421132HCID 67421132, compound

Product 1

HCID 67421683HCID 67421683, compoundYield 40%

Procedure

As described for Example 71, cyclopentylamine was converted, using 2-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid (100 mg, 0.29 mmol) instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid, to the title compound (48 mg, 40%) which was obtained as an off-white solid. MS: m/e=413.1 [M+H]+.

Sources & evidence

ORD record: ord-e5086303bb7f435dabee3e9e01ed3366
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

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