Benzoic acid, 3-fluoro-, ethyl ester → HCID 67421715, compound

HRID 2219383Notes

Reaction equation

HRID 2219383 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][NH:16][CH:17]=3)=[C:11]([CH3:18])[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:19]([O:21][C:22](=[O:30])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25](F)[CH:24]=1)[CH3:20]>>[CH2:19]([O:21][C:22](=[O:30])[C:23]1[CH:28]=[CH:27][C:26]([N:14]2[C:13]([C:12]3[C:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)=[N:9][O:10][C:11]=3[CH3:18])=[CH:17][N:16]=[CH:15]2)=[CH:25][CH:24]=1)[CH3:20]

Participants

3

Reactant 2

HCID 67975Benzoic acid, 3-fluoro-, ethyl esterHCID 178434992HCID 178434992, compound

Product 1

HCID 67421715HCID 67421715, compoundYield 53%

Procedure

As described for Example 1, 3-(3-fluoro-phenyl)-4-(1H-imidazol-4-yl)-5-methyl-isoxazole (3.89 g, 16.0 mmol) was converted, using 3-fluorobenzoic acid ethyl ester instead of 4-fluoroacetophenone, to the title compound (3.34 g, 53%) which was obtained as a yellow solid. MS: m/e=391.9[M+H]+.

Sources & evidence

ORD record
ord-671d54b2937d41429b80433e7c3efa09
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…