Cyclopentylamine → HCID 67420955, compound

HRID 2219387Notes

Reaction equation

[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([C:14]2[C:18]([C:19]3[N:20]=[CH:21][N:22]([C:24]4[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=4)[C:27](O)=[O:28])[CH:23]=3)=[C:17]([CH3:33])[O:16][N:15]=2)[CH:11]=[CH:12][CH:13]=1>>[CH:1]1([NH:6][C:27](=[O:28])[C:26]2[CH:30]=[CH:31][CH:32]=[C:24]([N:22]3[CH:23]=[C:19]([C:18]4[C:14]([C:10]5[CH:11]=[CH:12][CH:13]=[C:8]([F:7])[CH:9]=5)=[N:15][O:16][C:17]=4[CH3:33])[N:20]=[CH:21]3)[CH:25]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 67421104HCID 67421104, compound

Product 1

HCID 67420955HCID 67420955, compoundYield 59%

Procedure

As described for Example 71c, cyclopentylamine was converted, using 3-{4-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-imidazol-1-yl}-benzoic acid (100 mg, 0.28 mmol) instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid, to the title compound (70 mg, 59%) which was obtained as an off-white solid. MS: m/e=431.0 [M+H]+.

Sources & evidence

ORD record: ord-ac8e626ab4634c2fb10e53eb171b8f1a
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414061B2

Reaction notes

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