Cyclopentylamine → HCID 67420964, compound

HRID 2219399Notes

Reaction equation

HRID 2219399 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:18]([C:19]3[N:20]=[CH:21][N:22]([C:24]4[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=4)[CH:23]=3)=[C:17]([CH3:33])[O:16][N:15]=2)=[CH:10][CH:9]=1>>[CH:1]1([NH:6][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([N:22]3[CH:23]=[C:19]([C:18]4[C:14]([C:11]5[CH:12]=[CH:13][C:8]([F:7])=[CH:9][CH:10]=5)=[N:15][O:16][C:17]=4[CH3:33])[N:20]=[CH:21]3)=[CH:25][CH:26]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 67419925HCID 67419925, compound

Product 1

HCID 67420964HCID 67420964, compoundYield 76%

Procedure

As described for Example 71c, cyclopentylamine was converted, using 4-{4-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-imidazol-1-yl}-benzoic acid (56 mg, 0.17 mmol) instead of 4-[4-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazol-1-yl]-benzoic acid, to the title compound (54 mg, 76%) which was obtained as an off-white solid. MS: m/e=430.1 [M+H]+.

Sources & evidence

ORD record
ord-25ddcfc9e4e541dcb3d1d98fad7afde3
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

Loading…