反应详情

温度

80 °C

To a solution of 5-cyclopropyl-3-phenyl-isoxazole-4-carboxylic acid ethyl ester (408 mg, 1.58 mmol) in ethanol (4 mL) was added aqueous sodium hydroxide (1 N, 3.17 mL, 3.17 mmol) and the mixture was stirred for 3 h at 80° C. The ethanol was distilled off and the residue diluted with water (5 mL) and acified with aqueous HCl (1N) to pH=1. The resulting suspension was filtered off and washed with water affording the title compound (314 mg, 86%) as a white solid. MS: m/e=230.3[M+H]+.

1. distillationThe ethanol was distilled off
2. additionthe residue diluted with water (5 mL)
3. filtrationThe resulting suspension was filtered off
4. washwashed with water affording the title compound (314 mg, 86%) as a white solid