Hydrogen Bromide → HCID 86613563, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-methoxymethyl-3-phenyl-isoxazole-4-carboxylic acid chloride (11.16 g, 44 mmol) in dry ether (350 mL) was added diazomethane solution in ether (0.1 N, 100 mL) at iced-bath cooling temperature. The reaction was stirred for 2 h at 0° C. Aqueous solution of hydrobromic acid (>40 wt %, 100 mL) was then added dropwise to the reaction solution at iced-bath cooling temperature. After complete addition, the organic layer was separated, and the aqueous phase was extracted with ether. The combined ether solution was washed with water and brine, dried over magnesium sulphate and evaporated to afford the title compound (12.83 g, 94%) which was obtained as a light yellow liquid. MS: m/e=310.0/311.9 [M+H]+.

Provenance & Evidence