3-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazole → {3-(4-Fluoro-phenyl)-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazol-5-yl}-methanol

HRID 2219415Notes

Reaction equation

HRID 2219415 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=4)[CH:17]=3)=[C:11]([CH2:28][O:29]C)[O:10][N:9]=2)=[CH:4][CH:3]=1.FC1C=CC(C2C(C3N=CN(C4C=CC(C(=O)C)=CC=4)C=3)=C(COC)ON=2)=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]3[N:14]=[CH:15][N:16]([C:18]4[CH:23]=[CH:22][C:21]([C:24]([F:25])([F:26])[F:27])=[CH:20][CH:19]=4)[CH:17]=3)=[C:11]([CH2:28][OH:29])[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 237258553-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazoleHCID 67420992HCID 67420992, compound

Product 1

HCID 23725807{3-(4-Fluoro-phenyl)-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazol-5-yl}-methanolYield 100.9%

Procedure

As described for Example 140, 3-(4-fluoro-phenyl)-5-methoxymethyl-4-[1-(4-trifluoromethyl-phenyl)-1H-imidazol-4-yl]-isoxazole (417 mg, 1.13 mmol), instead of 1-(4-{4-[3-(4-fluoro-phenyl)-5-methoxymethyl-isoxazol-4-yl]-imidazol-1-yl}-phenyl)-ethanone, was converted to the title compound (460 mg, 95%) which was obtained as yellow solid. MS: m/e=403.9 [M+H]+.

Sources & evidence

ORD record
ord-1d43d8dbd02041dd832be9c2e03f1e3e
Source dataset
uspto-grants-2008_08
Patent number
US07414061B2

Reaction notes

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