Thionyl Chloride → HCID 87393347, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-(4-fluoro-phenyl)-5-methoxymethyl-isoxazole-4-carboxylic acid (2.51 g, 10.0 mmol) in thionyl chloride (4.0 mL) was added two drops of DMF, and the resulting reaction mixture was heated at 60° C. for 3 h. After cooling to room temperature, the mixture was concentrated under reduced pressure to afford the crude title compound (2.7 g, 100%) which was obtained as a light yellow liquid and used directly in the next step without further purification.

Provenance & Evidence