Trifluoroacetic acid → HCID 23725533, compound

Participants

Reaction Steps

To a solution of 4-[2-benzyloxymethyl-1-(4-nitro-phenyl)-1H-imidazol-4-yl]-5-methyl-3-phenyl-isoxazole (200 mg, 0.43 mmol) in DCM (10 mL) at 0° C. was added trifluoroacetic acid (0.98 mL) and trifluoromethanesulfonic acid (0.06 mL) and the resulting mixture stirred vigorously for 3 h. The mixture was then poured onto a saturated solution of sodium hydrogen carbonate and stirred for 30 min. The resulting precipitate was then filtered off, washed with water and then dried to afford the title compound (91 mg, 56%) which was obtained as a white solid. MS: m/e=377.4 [M+H]+.

Provenance & Evidence