HCID 23725533, compound → HCID 23725535, compound

Participants

Reaction Steps

To a solution of [4-(5-methyl-3-phenyl-isoxazol-4-yl)-1-(4-nitro-phenyl)-1H-imidazol-2-yl]-methanol (50 mg, 0.13 mmol) in DCM (3 mL) was added manganese(IV) oxide (46 mg, 0.5 mmol) and the resulting mixture stirred at room temperature for 5 h. The mixture was then filtered over dicalite and washed with DCM. Then another aliquot of manganese(IV) oxide (46 mg, 0.5 mmol) was added and the mixture stirred overnight and then another aliquot of manganese(IV) oxide (120 mg, 1.3 mmol) was added and the mixture stirred for 5 h. The mixture was then filtered over dicalite and washed with DCM and evaporated. Purification by chromatography (SiO2, heptane:ethyl acetate=100:0 to 80:20) afforded the title compound (16.4 mg, 33%) which was obtained as a yellow gum. MS: m/e=375.3 [M+H]+.

Provenance & Evidence