HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylbenzyl alcohol → HCID 23725589, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylbenzyl alcohol | HCID 11505 | — |
| Reactant | 3-Chlorobenzyl alcohol | HCID 70117 | — |
| Reactant | HCID 23725534 | HCID 23725534 | — |
| Product | HCID 23725589 | HCID 23725589 | 60% |
Reaction Steps
As described for Example 153, 4-[2-chloromethyl-1-(4-nitro-phenyl)-1H-imidazol-4-yl]-5-methyl-3-phenyl-isoxazole (100 mg, 0.25 mmol), using 3-chlorobenzyl alcohol and KI (8.4 mg, 0.05 mmol) instead of 4-methylbenzyl alcohol, was converted to the title compound (76 mg, 60%) which was obtained as a light yellow solid. MS: m/e=501.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07414061B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-7a1a593123e74a38851f10fc3b0c4c8f |
| Source note | uspto-grants-2008_08 |