Chloroform → HCID 11688663, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 ml microwave reaction vessel were dissolved 50 mg (0.134 mmol) 3-Iodo-6-methyl-pyridine-2-carboxylic acid (3-chloro-phenyl)-amide and 16 mg (0.168 mmol, 1.25 equiv.) of 3-aminopyridine in 2 ml of dioxane. Cesium carbonate (61 mg, 188 mmol, 1.4 equiv.) were added and argon was bubbled through the suspension for 3 min. Then Xanthphos (26 mg, 0.044 mmol, 0.33 equiv.) and Pd2(dba)3.CHCl3 14 mg (0.013 mmol, 0.1 equiv.) were added and the mixture was heated for 30 min at 150° C. under microwave irradiation. The mixture was diluted with methylene chloride, filtered and concentrated in vaccuo. The resulting dark brown oil (129 mg) was purified by flash chromatography (gradient: heptane/ethyl acetate 4:1 to 3:2) to yield the title compound as a yellow solid (total 11 mg, 24%), MS (ISP): m/e=339.1, 341.1 (M+H+).

Provenance & Evidence