Hydrochloric Acid → HCID 86607567, compound

Participants

Reaction Steps

A HCl saturated solution of [2-(2-Chloro-pyridin-4-ylcarbamoyl)-6-methyl-pyridin-3-yl]-carbamic acid tert-butyl ester (0.50 g, 1.38 mmol) in methanol (13.0 ml) was stirred overnight at r.t. and evaporated to dryness in vaccuo. The residual hydrochloride salt was taken up in 15 ml of water, the pH was adjusted to 8.5 by addition of sat. sodium carbonate solution. The resulting suspension was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate and concentrated in vaccuo to yield the title compound as a white solid (total 0.35 g, 97%), MS (ISP): m/e=263.1, 265.1 (M+H+).

Provenance & Evidence