3-Bromopyridine → HCID 11602237, compound

Participants

Reaction Steps

The title compound, was prepared in accordance with the general method of example 4, step 2 using 2-amino-5-fluoropyridine instead of 2-chloro-4-aminopyridine to yield [2-(5-Fluoro-pyridin-2-ylcarbamoyl)-6-methyl-pyridin-3-yl]-carbamic acid tert-butyl ester as a white solid. MS (ISP): m/e=347.0 (M+H+). Boc-deprotection as described in example 4 step 3 yielded 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide as a light yellow solid, MS (ISP): m/e=247.3 (M+H+). Palladium catalysed arylation with 3-Bromopyridine as described in example 4 step 4 yielded the final product as a light yellow solid, MS (ISP): m/e=324.3 (M+H+).

Provenance & Evidence