反应详情

To a mixture of R-epichlorohydrin (9.8 g, 106 mmol) and 4-cyclohexylphenol (3.73 g, 21.2 mmol) in acetonitrile (40 ml) was added cesium carbonate (6.9 g, 21.2 mmol). The mixture was heated at reflux for 3 hours. The reaction mixture was cooled, poured into water (100 mL) and extracted twice with EtOAc. The organic phases were combined and washed with water, brine, dried (Na2SO4), concentrated and dried under high vacuum overnight to give the title compound.

1. temperatureThe mixture was heated
2. temperatureat reflux for 3 hours
3. temperatureThe reaction mixture was cooled
4. extractionextracted twice with EtOAc
5. washwashed with water, brine
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated
8. customdried under high vacuum overnight