3-Bromopyridine → HCID 11573128, compound

Participants

Reaction Steps

The title compound, was prepared in accordance with the general method of example 4, step 2 using 1-Methyl-1H-pyrazol-3-ylamine instead of 2-chloro-4-aminopyridine to yield [6-Methyl-2-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-pyridin-3-yl]-carbamic acid tert-butyl ester as an off-white solid. MS (ISP): m/e=332.0 (M+H+). Boc-deprotection as described in example 4 step 3 yielded 3-Amino-6-methyl-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide as an off-white solid, MS (ISP): m/e=232.3 (M+H+). Palladium catalysed arylation with 3-Bromopyridine as described in example 4 step 4 yielded the final product as a light brown solid, MS (ISP): m/e=309.1 (M+H+).

Provenance & Evidence