5-Bromonicotinonitrile → HCID 86607575, compound

HRID 2219490Notes

Reaction equation

HRID 2219490 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.BrC1C=C(C#N)[CH:29]=[N:30]C=1>>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[N:20][CH:21]=[C:22]([C:29]#[N:30])[CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 7367935-BromonicotinonitrileHCID 11522606HCID 11522606, compound

Product 1

HCID 86607575HCID 86607575, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide (example 5) in accordance with the general method of example 20 using 5-Bromo-3-cyanopyridine instead of 3-Bromo-4-methylpyridine to yield the final compound as a light yellow crystalline solid, MS (ISP): m/e=345.0 (M+H+).

Sources & evidence

ORD record
ord-8c149a793ec44845a8b350cd82c7eb75
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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