1-Bromo-3-fluorobenzene → HCID 86607576, compound

HRID 2219491Notes

Reaction equation

HRID 2219491 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=N[CH:21]=[CH:22][CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.BrC1C=CC=[C:28]([F:32])C=1>>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:28]([F:32])[CH:19]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 140821-Bromo-3-fluorobenzeneHCID 11522606HCID 11522606, compound

Product 1

HCID 86607576HCID 86607576, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (2-methyl-pyridin-4-yl)-amide (example 5) in accordance with the general method of example 20 using 1-Bromo-3-fluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=337.3 (M+H+).

Sources & evidence

ORD record
ord-1ac6b1c4013a47faa517192676a75793
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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