3-Bromobenzonitrile → HCID 11501123, compound

HRID 2219497Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])=[N:6][CH:7]=1.Br[C:26]1C=C(C=C[CH:33]=1)C#N>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:18]3[CH:19]=[CH:33][CH:26]=[C:22]([C:21]#[N:20])[CH:23]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 233813-Bromobenzonitrile

HCID 11602237HCID 11602237, compound

Product 1

HCID 11501123HCID 11501123, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide (example 8) in accordance with the general method of example 20 using 3-Bromobenzonitrile instead of 3-Bromo-4-methylpyridine to yield the final compound as a yellow crystalline solid, MS (ISP): m/e=348.0 (M+H+).

Sources & evidence

ORD record: ord-caec5b9c99284e6abe5d2bbcd4d88d9e
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07414060B2

Reaction notes

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