1-Bromo-3,5-difluorobenzene → HCID 11523311, compound

HRID 2219498Notes

Reaction equation

HRID 2219498 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17]C3C=NC=CC=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])=[N:6][CH:7]=1.Br[C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[C:28]([F:33])[CH:27]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:16]([NH:17][C:26]3[CH:31]=[C:30]([F:32])[CH:29]=[C:28]([F:33])[CH:27]=3)=[CH:15][CH:14]=[C:13]([CH3:24])[N:12]=2)=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 1363131-Bromo-3,5-difluorobenzeneHCID 11602237HCID 11602237, compound

Product 1

HCID 11523311HCID 11523311, compound

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide (example 8) in accordance with the general method of example 20 using 1-Bromo-3,5-difluorobenzene instead of 3-Bromo-4-methylpyridine to yield the final compound as an off-white crystalline solid, MS (ISP): m/e=358.9 (M+H+).

Sources & evidence

ORD record
ord-04a22df1fd8540b5a0b1aaac5e6e094b
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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