5-Bromonicotinonitrile → 3-(5-Cyano-pyridin-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

HRID 2219500Notes

Reaction equation

HRID 2219500 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])[S:5][CH:6]=1.BrC1C=C(C#N)[CH:28]=[N:29]C=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[C:15]([NH:16][C:17]3[CH:18]=[N:19][CH:20]=[C:21]([C:28]#[N:29])[CH:22]=3)=[CH:14][CH:13]=[C:12]([CH3:23])[N:11]=2)=[O:9])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 7367935-BromonicotinonitrileHCID 115371406-Methyl-3-(pyridin-3-ylamino)-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

Product 1

HCID 116888773-(5-Cyano-pyridin-3-ylamino)-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide

Procedure

The title compound, was prepared from 3-Amino-6-methyl-pyridine-2-carboxylic acid (4-methyl-thiazol-2-yl)-amide (example 14) in accordance with the general method of example 20 using 5-Bromo-3-cyanopyridine instead of 3-Bromo-4-methylpyridine to yield the final compound as an off-white solid, MS (ISP): m/e=351.1 (M+H+).

Sources & evidence

ORD record
ord-3488589b3dcd4a99a17031a33e3189a7
Source dataset
uspto-grants-2008_08
Patent number
US07414060B2

Reaction notes

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